5 Natural Supplements to Support Mental Health

by HelloMD Staff

Anyone who has ever struggled with a mental disorder such as anxiety or depression knows mental health is not a perfect state of mind, but rather a constant state of mindfulness. Mental Health requires regular maintenance, monitoring, and responsiveness to changes. As part of a body that needs exercise, sleep, and fuel, our mind will tell us when it needs something if we listen.

If your mind is speaking to you—maybe you’re feeling unmotivated, overwhelmed or anxious—there are ways to treat yourself, or add to your therapy or conventional medications. Here are a few of Nature’s best supplements for mental health:

Vitamin D

Sunshine is a mood-brightener on the eyes--and on the skin, it turns out, as UV must penetrate the skin to trigger Vitamin D synthesis in the body. You need Vitamin D to absorb calcium, and a growing number of psychiatrists and physicians are prescribing it to help with symptoms of depression.

According to the CDC, roughly one-third of women in the U.S. are at risk of Vitamin D deficiency or inadequacy. Levels of 30-50 ng/mL of blood seem to be what health professionals are currently targeting, and 800-2000 or more international units (UIs) of vitamin D are the typical daily dose.

Low levels of vitamin D are caused by sunscreen prohibiting UV penetration, and by spending workdays indoors as the rays needed to make vitamin don’t travel through glass. Living in northern climes does not affect D levels, according to the Institute of Medicine, Food and Nutrition. Ask for a vitamin D test at your next checkup to assess your level.

Fish or Flaxseed Oil (Omega-3s)

More than a decade ago, scientists studying human longevity began to discover an inverse correlation between fish consumption and depression. Since then, Omega-3s have become the alpha supplement for heart and health. The body cannot synthesize Omega-3 fatty acids itself, so we must consume them. And, if you’re a vegetarian or don’t consume fish three times a week, you probably need this supplement.

Omega-3s’ mental health properties are said to come from their ability to readily absorb into the central nervous system and facilitate your mood-regulating neurotransmitters, dopamine, and serotonin. Fish Oil supplements contain eicosapentaenoic acid (EPA), which aids in the release of serotonin, as well as docosahexaenoic acid (DHA), which supports your brain’s pathways, according to the Oakland Research Institute For vegetarians, Flaxseed Oil is a great alternative and is the richest source of a third, health-giving omega-3, alpha-linolenic acid (ALA). Studies indicate omega-3 supplements will at the very least do no harm, and are widely recommended.


With medical marijuana legalized in the majority of US states (33 states) and a growing body of research confirming the efficacy of cannabis compound cannabidiol (CBD). HelloMD’sDr. Richard Kim confirms that CBD strongly supports the production of mood-boosting neurotransmitters, especially serotonin, that it can be as effective as prescription medications for mood disorders. CBD on its own also happens to be non-intoxicating, which is a reason why many people may prefer it over THC, its psychoactive counterpart.

As a supplement to support mental health, CBD acts on the nervous system’s own complex network of cannabinoid receptors, as well as the brain’s serotonin pathways, to regulate mood. One study from 2018 published in the Journal of Affective Disorders found that cannabis low in THC and high in CBD seemed to reduce depression symptoms, while patients reported that high-THC/high-CBD cannabis worked best against stress.

CBD can be derived from hemp, which has 0.03% THC or less. Hemp-derived CBD is available in your local pharmacy and even the grocery store in most states. CBD may also be extracted from cannabis marijuana, this is most often called full spectrum as it may have a balance of THC to CBD and a variety of other cannabinoids. Full-spectrum CBD is found in your local dispensary whether that is a medical or recreational retail outlet. HelloMD advises experimenting to find the type and amount of CBD for your best balance, as cannabis can affect people in different ways.

Vitamin B Complex with Folate

Vitamin B is actually 8 vitamins, the most known being folate, B6, B12, thiamin, riboflavin and niacin. B vitamins are important to DNA synthesis and crucial in neurological function. Vitamin B12 is often recommended to the elderly complaining of issues with impaired cognition, according to Psychology Today, which also reports that low levels of folate, niacin and thiamin were associated with cognitive impairment in general.) Low levels of folate and B12 have been found in studies of depressive patients, as well, according to an article in the Journal of Psychopharmacology.

Look for a supplement with a well-balanced complex of B vitamins, including: Methyl Folate (not Folic Acid, as 40% of women cannot synthesize it), Methylcobalamin as it is a form of B12 that supports brain and nerve tissue, and Pyridoxal 5-Phosphate (P-5-P) as it is a form of B6 that controls the metabolism of amino acids and aids in the production of neurotransmitters including serotonin.

Melatonin as Needed + Women’s Multivitamin

The best thing you can do for your mental health is to get your sleep, eat a balanced diet and exercise. While there are unfortunately no supplements for exercise, you can give your body an assist with two other basic needs.

Sleep is the panacea of mental health, and lack of it dramatically impairs emotional regulation. In fact, Harvard Health research found sleep problems may be a risk factor for developing an anxiety disorder, and preceded depression 69% of the time. Beyond employing the practices of sleep hygiene, supplementing with Melatonin, the hormone that regulates our sleep-wake cycle, helps insomniacs young and old sleep and can help establish a more regular sleep routine.

A diet for good mental and physical health includes 9 servings of produce, 3 of dairy, 6 of whole grains and 100 grams of protein—every day. If you’re vegetarian, it’s harder to get your proteins. Vegans also miss dairy. Millions more women who eat out a couple of nights a week or don’t stick to whole foods have below-adequate micronutrient levels.

Many doctors recommend multivitamins, and research that claims multivitamins do nothing has been recently challenged. The Harvard School of Public Health calls multivitamins your “nutrition insurance policy,” and advises to avoid mega-dose multivitamins. In fact, they say the least expensive options are often just right.

When adding supplements to your lifestyle, do so one at a time to get a feel for their individual effects and home in on the best dosage for you. If you have symptoms of severe anxiety or depression, supplements should be discussed with a qualified healthcare provider first.

Author: Amie Duhamel